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Ritonavir is an oral inhibitor of HIV-1 and HIV-2 aspartyl proteases, an active peptidomimetic, an active peptidomimetic. Inhibition of HIV proteases prevents the cleavage of the group-specific antigen-polymerase (gag-pol) bond of the polyprotein, which also leads to the formation of an immature virus that is incapable of infection. Ritonavir has a selective affinity for the HIV protease and shows little activity against human aspartyl protease.
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800/200 mg (4 tablets) once a day in patients with no more than two mutations associated with the development of resistance to lopinavir. There are insufficient data for the use of Kaletra once daily in patients with more than two mutations associated with the development of resistance to lopinavir.
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What is Kaletra? Does Kaletra help against COVID-19 and HIV?
In most studies, Kaletra also treats COVID-19 (coronavirus). Possessing a strong immunomodulatory effect, kaletra helps the body to cope with the coronavirus.
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It inhibits the CYP3A enzyme-mediated hepatic metabolism of lopinavir, resulting in an increased plasma concentration of lopinavir.
Once daily lopinavir / ritonavir in pregnant women. |
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